亚庇亚洲城卖游泳衣吗

  • <tr id='TIlHpA'><strong id='TIlHpA'></strong><small id='TIlHpA'></small><button id='TIlHpA'></button><li id='TIlHpA'><noscript id='TIlHpA'><big id='TIlHpA'></big><dt id='TIlHpA'></dt></noscript></li></tr><ol id='TIlHpA'><option id='TIlHpA'><table id='TIlHpA'><blockquote id='TIlHpA'><tbody id='TIlHpA'></tbody></blockquote></table></option></ol><u id='TIlHpA'></u><kbd id='TIlHpA'><kbd id='TIlHpA'></kbd></kbd>

    <code id='TIlHpA'><strong id='TIlHpA'></strong></code>

    <fieldset id='TIlHpA'></fieldset>
          <span id='TIlHpA'></span>

              <ins id='TIlHpA'></ins>
              <acronym id='TIlHpA'><em id='TIlHpA'></em><td id='TIlHpA'><div id='TIlHpA'></div></td></acronym><address id='TIlHpA'><big id='TIlHpA'><big id='TIlHpA'></big><legend id='TIlHpA'></legend></big></address>

              <i id='TIlHpA'><div id='TIlHpA'><ins id='TIlHpA'></ins></div></i>
              <i id='TIlHpA'></i>
            1. <dl id='TIlHpA'></dl>
              1. <blockquote id='TIlHpA'><q id='TIlHpA'><noscript id='TIlHpA'></noscript><dt id='TIlHpA'></dt></q></blockquote><noframes id='TIlHpA'><i id='TIlHpA'></i>
                Scientific Reports 2016;6:17029
                發布時間:2016-02-03 瀏覽次數:

                Depression is one of the major side effects of interferon alpha (IFN-α) treatment, but the molecular mechanism underlying IFN-α-induced depression remains unclear. Several studies have shown that the serotonin receptors 5-HTR1b and 5-HTR4 play key roles in the anti-depression effects associated with p11 (S100A10). We investigated the effects of IFN-α on the regulation of p11, 5-HTR1b and 5-HTR4 in mice and human neuroblastoma cells (SH-sy5y). We found that intraperitoneal injection with IFN-α in Balb/c mice resulted in an increased immobility in FST and TST, and potently lowered the protein levels of p11, 5-HTR1b and 5-HTR4 in the hippocampus or cingulate gyrus. IFN-α significantly down-regulated the protein levels of p11, 5-HTR1b and 5-HTR4 in SH-sy5y cells, in a time- and dose-dependent manner. Our study revealed that over-expression of p11 could prevent the IFN-α-induced down-regulation of 5-HTR1b and 5-HTR4. The results indicated that IFN-α treatment resulted in p11 down-regulation, which subsequently decreased 5-HTR1b and 5-HTR4 in vitro or in vivo. Our findings suggested that p11 might be a potential regulator on 5-HTR1b and 5-HTR4 as well as a predictor of or a therapeutic target for IFN-α-induced depression.